Masui. The Japanese journal of anesthesiology
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Randomized Controlled Trial
[Efficacy and safety of remifentanil-based regimen for postoperative pain management in abdominal surgery patients: a double-blind study with low-dose remifentanil infusion of 0.02 microg x kg(-1) x min(-1)].
Remifentanil is a powerful analgesic with fast onset and ultra-short duration of action. Its context-sensitive half-time is consistently short even after a prolonged infusion. Remifentanil is effective for providing better postoperative analgesia, but this method is not generally accepted in Japan. The present study was conducted to document efficacy and safety of low-dose remifentanil infusion in postoperative patients. ⋯ Remifentanil infusion at 0.02 microg x kg(-1) x min(-1) can safely be used without any serious adverse events, while it may not be enough for postoperative analgesia. The best dosage of this drug for postoperative analgesia remains to be elucidated.
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Randomized Controlled Trial
[Effect of concentration on counting numbers on pain induced by injection of propofol].
One of the concerns in the use of propofol is the pain on injection of the drug. Many attempts were made to prevent such pain, none of which has been reasonably successful. We hypothesized that the pain is attenuated when the patient is directed to concentrate on counting numbers while propofol is injected. ⋯ Intensive counting did not reduce the incidence of pain on injection of propofol. Age and the degree of pain on inserting intravenous cannula can be a useful predictor for an intolerable pain on injection of propofol.