Middle East journal of anaesthesiology
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Middle East J Anaesthesiol · Jun 2011
Randomized Controlled Trial Comparative StudyEffect of propofol titration v/s bolus during induction of anesthesia on hemodynamics and bispectral index.
Propofol when given as 2 mg/kg IV bolus for induction of anesthesia is known to cause hypotension requiring vasopressors. The objective of our study was to compare Propofol 2 mg/kg single IV bolus (Precalculated group, PG) with the titration of Propofol (Titration group, TG) to clinical parameters as 10 mg IV increments every 3 seconds on hemodynamic Parameters and Bispectral Index (BIS), during induction. The effect of titration on dose requirement for induction was also evaluated. ⋯ Titration of Propofol reduces hemodynamic changes, dose requirement and is able to achieve same level of BIS as in bolus.