Revista española de anestesiología y reanimación
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Rev Esp Anestesiol Reanim · Mar 2004
Randomized Controlled Trial Comparative Study Clinical Trial[Clinical effects and pharmacokinetics of ropivacaine and bupivacaine for epidural analgesia during labor].
To compare the analgesic efficacy, pharmacokinetics and histamine release of ropivacaine and bupivacaine with fentanyl in continuous epidural perfusion during labor and childbirth. ⋯ Analgesia was equally effective in both groups, without adverse maternal-fetal effects, with spontaneous micturition and absence of motor blockade in both groups. The plasma concentrations were higher with ropivacaine but were not toxic.