Journal of the Medical Association of Thailand = Chotmaihet thangphaet
-
Randomized Controlled Trial
Effect of oral probiotics supplementation in the prevention of necrotizing enterocolitis among very low birth weight preterm infants.
Necrotizing enterocolitis (NEC) is the most serious gastrointestinal problem in very low birth weight preterm infants. Multiple risk factors activate the inflammatory cascade leading to high expressions of pro-inflammatory mediators causing bowel injury in NEC. The anti-inflammatory effect of probiotics is due to the inhibition and reduction of inflammatory signal in intestinal epithelium. ⋯ In this study, there was no difference in incidence of NEC stage ≥ 2 between the two groups. No adverse effects of probiotics supplementation were observed.