Journal of opioid management
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Randomized Controlled Trial
A 12-week extension study to assess the safety and tolerability of naloxegol in patients with noncancer pain and opioid-induced constipation.
To compare the long-term safety and tolerability of naloxegol with placebo in patients with opioid-induced constipation (OIC) and noncancer pain. ⋯ Naloxegol was generally safe and well tolerated in this 12-week extension study in patients with noncancer pain and OIC.