Journal of the Indian Medical Association
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Randomized Controlled Trial Comparative Study
Comparative study of postoperative analgesia and sedation after upper abdominal surgery with thoracic epidural administration of bupivacaine with/without midazolam.
Currently continuous epidural administration of local anaesthetics with opioids is widely used for postoperative analgesia. To avoid the side-effects of opioids a drug that can replace opioids is most welcome. Midazolam not only has no side-effects but also has the advantages of sedation and amnesia. ⋯ Statistically significant differences in pulse, BP, RR and SpO2 were not seen. Better sedation, analgesia scores and amnesia were noted in patients belonging to group B as compared to patients of group A. This combination may thus replace routinely used combinations of opioids and local anaesthetics.