The American review of respiratory disease
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Am. Rev. Respir. Dis. · Sep 1980
Immunologic identification of elastin-derived peptides in the serums of dogs with experimental emphysema.
Pulmonary emphysema is a disease in which peptides formed by the enzymatic degradation of the amorphous component of interstitial elastin may be release from the lung. In order to provide a test that can monitor the destruction of lung elastin invivo, we developed a hemagglutination inhibiton assay that specifically and quantitatively measure elastin-derived peptides in serum. ⋯ There was a good correlation between the maximal concentration of elastin derived peptides found in the serums and the amount of elastase administered to the animal. This immunologic method may be useful in following the progression of experiment emphysema.
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Am. Rev. Respir. Dis. · Sep 1980
Interalveolar pores in mouse lung. Regional distribution and alterations with age.
Quantitative analysis of the regional distribution of interalveolar pores in the lungs of BALB/c mice 1 to 28 months of age (n = 25) was performed by scanning electron microscopy. In all the age groups examined, the subpleural and peribronchiolar alveoli had significantly more pores than the midzonal region (p < 0.01). No significant changes were noted in the number of pores per alveolus between 3 and 26 months of age in the midzonal, peribronchiolar, and subpleural alveoli. We concluded that (1) intralevolar pores are regionally distributed in the lungs of BALB/c mice by 3 months of age, and (2) the number of pores do not significantly change with increasing age during the first 26 months.