Anesteziologiia i reanimatologiia
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Anesteziol Reanimatol · May 1999
Review Comparative Study[Choice of drugs for general anesthesia in patients with arrhythmia].
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Anesteziol Reanimatol · May 1999
Review Comparative Study[Latex allergy: a current medical problem].
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Anesteziol Reanimatol · May 1999
Review Comparative Study[Replenishment of circulating blood volume by the use of colloid solutions].
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Anesteziol Reanimatol · May 1999
Review[Clinical experience in the use of clonidine in regional anesthesia and early postoperative period (1984-1989)].
Clonidine attracts attention as a sole agent for local anesthesia. This review analyzes the role of alpha 2-adrenergic agents in modern regional anesthesiology, both practical and experimental. Recent controlled studies showed that an alpha 2-adrenoreceptor clonidine administered spinally is characterized by a dose-dependent antinociceptive effect and is as effective as epinephrine in prolonging local anesthetic blocks. ⋯ Regional administration of clonidine involves side effects, such as hypotension, bradycardia, and sedation. Minimization of the dose of alpha 2-adrenergic agonists minimizes the complications. Regional clonidine effects (analgesia, hemodynamic changes, and sedation) and their recognized mechanisms of action are described.