Anesteziologiia i reanimatologiia
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Anesteziol Reanimatol · Mar 2006
Randomized Controlled Trial[Effect of anesthesia with xenon and nitrous oxide with fentanyl on dynamics of cellular immunity and cytokines].
Immunological parameters were studied at randomization in 60 surgical patients during the similar operation--cholecystectomy made under combined endotracheal low-flow general anesthesia using N2O:O2+fentanyl in 32 patients and Xe:O2 in 28 patients. The time course of changes in cellular immunity and cytokines was closely related to the type of an anesthetic. ⋯ The differences in the action of the anesthetics were due to the fact that Xe had a greater narcotic potential, a protective action on neuroendocrine function, and no toxicity. Xe is indicated to patients with baseline immunodeficiency.
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Anesteziol Reanimatol · Mar 2006
Randomized Controlled Trial[Preoperative hypervolemic hemodilution with 6% hydroxyethyl starch 130/0,4 (HES 130/ 0.4) solution as a way of reducing needs for donor blood transfusion].
The efficacy of hypervolemic hemodilution (HHD) in reducing the rate of donor blood transfusion is controversely discussed. The present prospective, randomized, clinical study analyzes the impact of HHD with 6% hydroxyethyl starch (HES) 130/0.4 solution on the rate transfusion, laboratory parameters, and the incidence of complications as compared with those in the control group receiving no preoperative HHD. ⋯ Preoperative HHD in patients undergoing surgery with expected >30% blood loss leads to decreased needs for blood transfusion. The method is safe and easy-to-use.