Postgraduate medicine
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Postgraduate medicine · Mar 2023
Randomized Controlled TrialRisk factors and prediction models of lymph node metastasis in papillary thyroid carcinoma based on clinical and imaging characteristics.
Papillary thyroid carcinoma (PTC) commonly presents with lymph node metastasis, which may be associated with worsened prognosis. This study aimed to comprehensively evaluate the risk factors of lymph node metastasis in PTC based on preoperative clinical and imaging data and to construct a nomogram model to predict the risk of lymph node metastasis. ⋯ Our study showed that independent risk factors for lymph node metastasis in PTC were sex, age, enlarged lymph node present on imaging, nodule diameter, and color Doppler TI-RADS grade. The nomogram constructed based on these independent risk factors can better predict the risk of lymph node metastasis.
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Postgraduate medicine · Mar 2023
Circulating platelets supply ST6Gal-1 in patients with IgA Nephropathy.
Our previous study showed ST6 β-galactoside α2,6-sialyltransferase 1 (ST6Gal-1) levels in plasma were associated with a slower progression of IgA nephropathy (IgAN). Platelets are the crucial regulator of cell surface glycosylation events in circulation by supplying glycosyltransferases. ⋯ In conclusion, human circulating platelets contain ST6Gal-1, which may be released by the activation of platelets in IgAN.