Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakológiai Egyesület lapja = official journal of the Hungarian Association of Psychopharmacology
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Neuropsychopharmacol Hung · Dec 2010
Review[Trazodone--its multifunctional mechanism of action and clinical use].
Trazodone is an antidepressant of the serotonin (5-HT2) antagonist and reuptake inhibitor class, and has been considered to act as a multifunctional drug. It is generally approved for the treatment of major depression, its efficacy is well-documented in elderly patients, and it has been widely used for replacement of benzodiazepines or benzodiazepine-type sleeping drugs due to its anxiolytic efficacy and sleep normalizing effect in depression. ⋯ It is weight neutral and does not decrease sexual function. The introduction of trazodone to the Hungarian market may decrease the widespread use of benzodiazepines in antidepressive treatment.