Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2018
Randomized Controlled Trial[Effect of different crystalloids on internal environment in patients with septic shock receiving early fluid resuscitation: a prospective randomized controlled trial].
To compare the effect of 0.9% NaCl solution, Ringer solution, and acetate sodium potassium magnesium calcium glucose solution (ASPMCG solution) on internal environment in patients with septic shock receiving early fluid resuscitation. ⋯ Chinese Clinical Trial Registry, ChiCTR-IOR-16009176.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2018
[Effect of Galectin-9/Tim-3 pathway on the polarization of M1/M2 subtype in murine macrophages induced by lipopolysaccharide].
To investigate the meaning and molecular mechanisms of Galectin-9/T-cell immunoglobulin mucin-3 (Tim-3) pathway on lipopolysaccharide (LPS) induced murine macrophage M1/M2 subtype polarization. ⋯ LPS regulates macrophage M1/M2 subtype polarization via Galectin-9/Tim-3 signaling pathway. Low-doses of LPS can limit the development of inflammation by accommodating the expression and secretion of Galectin-9 to polarize macrophages to M2. High-doses of LPS promotes the development of inflammation by down-regulating the expression and secretion of Galectin-9 to polarize macrophages to M1.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2018
[Effect of lung strain on breathing mechanics in dogs with acute respiratory distress syndrome].
To explore the effect of lung strain on breathing mechanics in dogs with acute respiratory distress syndrome (ARDS). ⋯ In animal ARDS models, the larger the lung strain, the higher the Pplat and lung stress during mechanical ventilation, VT originated for lung strain 2.0 and 2.5 may further reduce Cst in ARDS models, when lung strain over 1.5, Pplat and lung stress increased significantly, which exceeded the safe range of LPV (35 cmH2O and 25 cmH2O, respectively), and further aggravated ventilator induced lung injury (VILI).
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2018
Meta Analysis[Effectiveness of Xuebijing in treatment of multiple organ dysfunction syndrome: a Meta analysis].
To systematical evaluate the effect of Xuebijing injection in the treatment of multiple organ dysfunction syndrome (MODS). ⋯ Xuebijing injection may through its strong cytokines clearance, platelet increase and blood coagulation improvement to protect the organ function in patients with MODS, so as to reduce the mortality and improve the prognosis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2018
[Protective effects of endovascular cooling treatment on post-resuscitation syndrome and its mechanism].
To investigate the protective function of endovascular cooling method on post-resuscitation syndrome (PRS) in porcine cardiac arrest (CA) model and its mechanism. ⋯ The intravascular cooling therapy was a safe and effective method for inducing mild hypothermia after resuscitation. This cooling effect was fast and reliable, and the rewarming speed was controllable and stable. The protective mechanism of mild hypothermia on PRS may be related to inhibiting systemic inflammatory response and reducing vascular endothelial cell injury.