Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jun 2014
[Hypoxia/reoxygenation and lipopolysaccharide induced nuclear factor-ΚB and hypoxia-inducible factor-1α signaling pathways in intestinal epithelial cell injury and the interventional effect of emodin].
To observe pathological process of intestinal epithelial cells subjected to ischemia, ischemia/reperfusion injury and inflammation simulated hypoxia/reoxygenation (H/R) and lipopolysaccharide (LPS) challenged human fetal normal colonic cell (FHC) line in vivo, and to observe the changes when the assaulted intestinal epithelial cells were treated with emodin, in order to explore the possible intervention targets of emodin. ⋯ Both hypoxia and inflammation can activate the hypoxia pathway of HIF-1α and the pro-inflammatory pathway of NF-ΚB, but different stimuli cause varying degrees of activation in these two pathways. In H/R group, both pathways were weakened during reoxygenation. However, in H/R + LPS group, the proteins remained to show a relatively high expression during the process of reoxygenation. This may be related to the pathophysiological mechanism of intestinal ischemia/reperfusion injury: hypoxia/reperfusion injury and LPS act together to destroy the intestinal epithelial cells and induce gut-derived sepsis. Emodin may inhibit inflammation by blocking HIF-1α/NF-ΚB-COX-2 signaling pathways.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · May 2014
Randomized Controlled Trial[Study of timing of invasive and noninvasive sequential ventilation in patients with acute respiratory distress syndrome].
To investigate the timing and value of noninvasive ventilation (NIV) as a weaning tool immediately after early extubation in patients with acute respiratory distress syndrome (ARDS). ⋯ When PaO2/FiO2 reached 200-250 mmHg under the condition of low ventilation, sequential NIV facilitates the early discontinuation of mechanical ventilation in ARDS patients with surgical diseases, with shortening of duration of invasive mechanical ventilation, total mechanical ventilation, and the length of ICU stay.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · May 2014
[Influences and mechanisms of somatostatin on inflammation in endotoxin-induced acute lung injury mice].
To investigate the effects of somatostatin on inflammation in endotoxin-induced acute lung injury mice and its underlying mechanisms. ⋯ SST has significant protective effects on endotoxin-induced ALI via direct suppression of the TLR4-NF-ΚB cytokine pathway, thus alleviate lung tissue inflammation.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · May 2014
Randomized Controlled Trial[Effect of high positive end-expiratory pressure for mechanical ventilation in the treatment of neurological pulmonary edema].
To explore the effect of high positive end-expiratory pressure (PEEP) for the treatment of neurological pulmonary edema (NPE) in patients undergoing mechanical ventilation, and to look for the best mechanical ventilation strategy to improve the prognosis. ⋯ Prognosis can be improved in NPE patients with the use of high PEEP in mechanical ventilation.