Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Jan 2014
Randomized Controlled Trial[The significance of lactic acid in early diagnosis and goal-directed therapy of septic shock patients].
To investigate the application of lactic acid in early diagnosis and goal-directed therapy of septic shock, and to provide reference for the early clinical diagnosis and treatment of septic shock. ⋯ By blood lactic acid monitoring, inadequacy of organization perfusion i.e. septic shock can be found in the early stage, thus early intervention can be performed and improve resuscitation result and reduce the mortality of septic shock patients. Blood lactic acid ≥ 4 mmol/L can be used as one of the criteria for the diagnosis of septic shock, and 6-hour blood lactic acid < 2 mmol/L as a goal to guide shock treatment with obvious prognosis improvement.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Dec 2013
Randomized Controlled Trial[The protective effect of Xuebijing injection pretreatment on hepatic ischemia reperfusion injury and coagulopathy after excision of liver cancer].
To observe the protective effect of Xuebijing injection pretreatment on hepatic ischemia reperfusion (I/R) injury and coagulopathy in liver cancer patients undergoing excision of hepatic cancer after occlusion of hepatic blood flow. ⋯ Hepatic I/R injury and coagulopathy may occur in liver cancer patients undergoing resection of cancer with occlusion of hepatic blood flow. Xuebijing injection may inhibit the release of serum pro-inflammatory cytokines, thereby alleviate hepatic I/R injury and promote the recovery of intestinal function. But it does not offer protective effect on coagulopathy.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Dec 2013
Randomized Controlled Trial[The effect of low molecular heparin on the prognosis of severe pneumonia in elderly patients].
To investigate the effect of low molecular heparin on degree of severity and prognosis of severe pneumonia in elderly patients. ⋯ In elderly patients suffering from severe pneumonia, low molecular heparin may reduce APACHEII score, shorten mechanical ventilation time and length of ICU stay, and the prognosis may be improved.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Nov 2013
Randomized Controlled Trial[Clinical significance of dynamic monitoring of procalcitonin in guiding the use of antibiotics in patients with sepsis in ICU].
To investigate the significance of dynamic monitoring of procalcitonin (PCT) in guiding the use of antibiotics for treating patients with sepsis in intensive care unit (ICU). ⋯ Dynamic monitoring of PCT can effectively reduce antimicrobial drug use in ICU patients with sepsis, but there is no significant difference in patients' prognosis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2013
Randomized Controlled Trial Comparative Study[Comparison of the effect of fluid resuscitation as guided either by lactate clearance rate or by central venous oxygen saturation in patients with sepsis].
To compare the efficacy of fluid resuscitation as guided by lactate clearance rate (LCR) and central venous oxygen saturation (ScvO2) in patients with sepsis. ⋯ Both LCR and ScvO2 can be taken as the index in confirming the endpoint of fluid resuscitation for patients with severe sepsis and septic shock. Fluid resuscitation therapy under the guidance of LCR is accurate and reliable in patients with severe sepsis and septic shock.