Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2020
[Clinical study on optimal switching mode in sequential noninvasive-invasive mechanical ventilation for acute exacerbation of chronic obstructive pulmonary disease].
To explore the switch time of noninvasive-invasive mechanical ventilation sequential treatment for acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and effectively reduce the rate of tracheal intubation. ⋯ If patients with AECOPD have relative contraindications of NIV but still insist on using NIV, further risk stratification of NIV failure is needed. For those with RI, pH value, WBC abnormalities and sputum excretion drainage, the risk of choosing NIV is significantly increased. We need to pay more attention to the change of the condition and switch to IPPV in time to avoid exacerbation of the condition.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2020
[Study on the optimization of administration regimen of vancomycin in critical patients].
To observe the changing characteristics of pharmacokinetic and pharmacodynamic (PK-PD) parameters of vancomycin in critical patients under different drug regimens and to further explore the influencing factors. ⋯ At the same daily dose, Cmin can be increased and Cmax can be decreased by increasing the frequency of vancomycin administration, thus minimize the fluctuation of vancomycin serum concentration, but AUC0-24 h/MIC is not affected. Vancomycin administration regimen in severe patients should be optimized according to CCr, CLvancomycin and age.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2020
[Dexamethasone on alleviating lung ischemia/reperfusion injury in rats by regulating PI3K/AKT pathway].
To investigate the protective effect and mechanism of dexamethasone in lung ischemia/reperfusion injury (LIRI) rats. ⋯ Dexamethasone pretreatment can alleviate the intrapulmonary inflammatory response and lung injury caused by LIRI in rats. The mechanism of action is related to the polarization direction of pulmonary macrophagesvia activation of the PI3K/AKT pathway by dexamethasone.