Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2015
[Reproduction of a model of "two-hit" sepsis model with complication of pneumonia in rat].
To reproduce a clinically relevant "two-hit" model of sepsis complicated by pneumonia and to explore the correlation between "two-hit" and immune state. ⋯ The mortality of this "two-hit" model with complication of pneumonia 4 days after CLP was significantly higher than that of single sepsis model. The ability of bacteria clearance was decreased, and immunocyte apoptosis was exacerbated. These findings may be with the result of the occurrence of immunoparalysis in the mid stage of sepsis. The "two-hit" model reproduced on 7 days after CLP might suggest reconstruction of host immune function, and maybe associated with the recovery of immune response.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2015
Meta Analysis[Effect of early goal-directed therapy on mortality in patients with severe sepsis or septic shock: a Meta analysis].
To investigate whether early goal-directed therapy (EGDT) could improve the mortality rate in patients with severe sepsis or septic shock. ⋯ EGDT was associated with significant improvement in short-term mortality but not with long-term mortality in patients with severe sepsis or septic shock. Grade C was recommended by our study.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2015
Meta Analysis[Accuracy of procalcitonin for diagnosis of sepsis in adults: a Meta-analysis].
To assess the clinical value of procalcitonin (PCT ) in the diagnosis of sepsis in adults. ⋯ Our results indicate a moderate degree of value of PCT for diagnosis of sepsis in adult patients. The diagnostic accuracy in medical patients is higher than that in surgical patients. PCT is a good auxiliary biomarker for diagnosis of sepsis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2015
[The value of passive leg raising test in predicting fluid responsiveness in patients with sepsis-induced cardiac dysfunction].
To assess the value of passive leg raising (PLR) test in predicting fluid responsiveness in patients with sepsis-induced cardiac dysfunction. ⋯ In patients with sepsis-induced cardiac dysfunction, changes in SV and CO induced by PLR are accurate indices for predicting fluid responsiveness, but the changes in HR, MAP, SBP and PP cannot predict the fluid responsiveness.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Sep 2015
Meta Analysis[Effect of timing of initiation of renal replacement therapy on prognosis in septic patients with acute kidney injury: a Meta analysis].
To systemically review the effects of timing of initiation of renal replacement therapy (RRT) on prognosis in septic patients with acute kidney injury (AKI). ⋯ Early RRT could reduce the 28-day mortality in patients with septic AKI compared with late RRT, but it did not lower the total mortality.