Zhonghua wei zhong bing ji jiu yi xue
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2015
Randomized Controlled Trial[The effect of anticoagulant therapy on coagulation and inflammation markers in sepsis patients and its significance].
To study the effect of anticoagulant therapy with low molecular weight heparin (LMWH) on coagulation and inflammation markers in sepsis patients. ⋯ LMWH, which was given early in sepsis, can significantly down-regulate the expression of CD62p, D-dimmer, IL-6 and TNF-α, and reduce the incidence of MODS. Some indicators regarding coagulation and inflammation can be used as supplementary indicators to severity scores, and it may be able to improve the accuracy of scoring systems for sepsis.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Feb 2015
Randomized Controlled Trial[Effect of Xuebijing injection on hemodynamics and endothelial function in patients with severe sepsis: a prospective study].
To investigate the effects of Xuebijing injection on hemodynamics, cardiac function, and endothelial function in patients with severe sepsis in order to study the therapeutic effect of Xuebijing in the treatment of severe sepsis. ⋯ After treatment, HR, MAP, CVP, Lac, ScvO2, and Pv-aCO2 were improved in both groups compared with those before treatment, and the dosage of norepinephrine (NE) was decreased in Xuebijing group. Compared with control group, MAP at 5 days after treatment in Xuebijing group was significantly increased [mmHg (1 mmHg = 0.133 kPa): 74.9±10.7 vs. 70.2±6.6, P < 0.05], the dosage of NE was decreased [μg×kg-1×min-1: 0.01 (0.00, 0.22) vs. 0.10 (0.05, 0.80), P < 0.05], LVEF was significantly increased (0.617±0.125 vs. 0.533±0.129, P < 0.05), BNP was significantly decreased [ng/L: 117.3 (52.0, 443.0) vs. 277.2 (67.9, 2 370.2), P < 0.05], while VEGF showed no significant change (ng/L: 101.1±23.2 vs. 89.6±20.5, P > 0.05), and sFLT-1 was significantly decreased (ng/L: 245.7±86.2 vs. 295.1±95.1, P < 0.05). It was shown by Pearson coefficient bivariate correlation analysis that sFLT-1 was negatively correlated with MAP and ScvO2 (r = -0.569, P = 0.000; r = -0.341, P = 0.008) 5 days after treatment, while it was positively associated with Lac and acute physiology and chronic health evaluation II (APACHE II) score (r = 0.749, P = 0.000; r = 0.645, P = 0.000).
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2014
Randomized Controlled Trial[Effects of levosimendan on hemodynamics and cardiac function in patients with septic shock].
To evaluate the effects of levosimendan on hemodynamics and cardiac function in patients with septic shock. ⋯ Levosimendan can increase cardiac ejection function, reduce the heart blood and vascular preload, intrathoracic lung water, improve heart function and systemic hemodynamic indexes of patients with septic shock.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2014
Randomized Controlled Trial[Efficacy and safety of early rapid infusion of icy normal saline in patients after cardiopulmonary resuscitation].
To assess the feasibility, safety, and effectiveness of early rapid icy normal saline infusion to attain mild hypothermia in cardiac arrest patients. ⋯ The study shows that early rapid i.v. infusion of 4 centigrade normal saline is feasible, safe and effective for cerebral resuscitation.
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Zhonghua Wei Zhong Bing Ji Jiu Yi Xue · Oct 2014
Randomized Controlled Trial[Effects of the β-blockers on cardiac protection and hemodynamics in patients with septic shock: a prospective study].
To investigate the effects of β-blockers on cardiac protection and hemodynamic in patients with septic shock. ⋯ β-blockers (esmolol) can improve cardiac function and myocardial compliance, reduce the myocardial injury in patients with sepsis shock. Although β-blockers can decrease cardiac output, it has no influence on the circulation function and tissue perfusion.