Läkartidningen
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End-of-life sedation is not well defined in clinical medicine. The Swedish Society of Medicine, Delegation for Medical Ethics, arranged a Nordic expert workshop to discuss issues of terminology, indications, information and consent, follow up and teaching. It was concluded that the following issues must be part of the decision-making process: the diagnosis and prognosis must be correct, all other treatment options including psychological and existential support must have been tried, there must be consensus between the patient, the family and the staff about the situation and the proposed treatment. These discussions will be followed by clinical guidelines issued by the Society.
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The Cochrane collaboration has performed a meta-analysis of all studies found on the prevention of ankle ligament injuries, frequent in sports like soccer, European handball and basketball. Interventions include the use of modified footwear and associated supports, training programmes and health education. ⋯ The studies showed a significant reduction in the number of ankle sprains in individuals allocated to external ankle support. This reduction was greater for those with a previous history of ankle sprains.
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Sarcoidosis is characterised by lung accumulated activated T helper cells that are believed to be of central importance for the inflammatory reaction, which results in granuloma formation and in some patients in the development of fibrosis. It is generally considered that sarcoidosis is initiated and triggered by unknown antigen(s), resulting in disease in genetically predisposed individuals. ⋯ A remarkably strict correlation between lung accumulated T helper cells expressing a specific T cell receptor (AV2S3+) and HLA-DR17 was observed, indicating an immune attack against a specific target in the lungs. Future studies in this field may reveal how candidate antigens, identified by other techniques, play a role in the sarcoid inflammation.