British journal of obstetrics and gynaecology
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Br J Obstet Gynaecol · Sep 1993
Randomized Controlled Trial Multicenter Study Clinical TrialLow dose aspirin in hypertensive pregnant women: effect on pregnancy outcome and prostacyclin-thromboxane balance in mother and newborn.
To study the effect of daily treatment with 50 mg of aspirin (ASA) on the hypertensive pregnancy complications and on the production prostacyclin (PGI2) and thromboxane A2 (TxA2) in high risk pregnant women and their infants. ⋯ ASA did not prevent the rise of maternal hypertension, but improved fetal haemodynamic performance and reduced the need of intensive neonatal care. It inhibited strongly maternal thromboxane A2 but not PGI2 production and thus shifted the balance between PGI2/TxA2 to the dominance of the vasodilatory, anti-aggregatory side.
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Br J Obstet Gynaecol · Sep 1993
Randomized Controlled Trial Multicenter Study Clinical TrialComparative profiles of reliability, cycle control and side effects of two oral contraceptive formulations containing 150 micrograms desogestrel and either 30 micrograms or 20 micrograms ethinyl oestradiol.
To compare two oral contraceptive pills, both containing 150 micrograms desogestrel, but with either 20 micrograms (Mercilon) or 30 micrograms (Marvelon/Desolett) ethinyl oestradiol (EE), regarding reliability, cycle control and side effect profile. ⋯ Both pills have high contraceptive reliability and are well tolerated, but with the 150/20 combination the cycle control is less effective. However, in view of the potentially increased safety profile of the 150/20 combination, many women can be expected to accept some additional discomfort due to irregular bleeding.
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Br J Obstet Gynaecol · Jun 1993
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialA randomised prospective study comparing the new vacuum extractor policy with forceps delivery.
To compare assisted vaginal delivery by forceps with delivery by vacuum extractor, where a new vacuum extractor policy was employed which dictated the cup to be used in specific situations. ⋯ Assisted vaginal delivery using the new vacuum extractor policy is associated with significantly less maternal trauma than with forceps. Further studies are required to assess neonatal morbidity adequately.
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Br J Obstet Gynaecol · Aug 1992
Randomized Controlled Trial Multicenter Study Clinical TrialGenital tract infections associated with the intrauterine contraceptive device can be reduced by inserting the threads into the uterine cavity.
To study the influence of the position of the threads of an intrauterine contraceptive device (IUCD) on the development of genital tract infection. ⋯ Infectious complications in women using an IUCD are more frequent if the threads lead from the uterine cavity to the vagina. This problem can be reduced by inserting the threads so that they remain entirely within the uterine cavity, a feasible procedure now that an effective instrument for IUCD thread retrieval is available.