British journal of obstetrics and gynaecology
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Br J Obstet Gynaecol · Sep 1998
Randomized Controlled Trial Clinical TrialA randomised placebo controlled trial of oral misoprostol in the third stage of labour.
To compare oral misoprostol 400 microg with placebo in the routine management of the third stage of labour. ⋯ Shivering has been shown in this study to be a specific side effect of misoprostol administered orally in the puerperium. No serious side effects were noted. Misoprostol shows promise as a method of preventing postpartum haemorrhage. Because of the potential benefits for childbearing women, particularly those in developing countries, further research to determine its effects with greater certainty should be expedited.
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Br J Obstet Gynaecol · Jul 1998
Randomized Controlled Trial Multicenter Study Clinical TrialThe haemodynamic effects of ketanserin versus dihydralazine in severe early-onset hypertension in pregnancy.
To compare the haemodynamic efficacy of ketanserin (a selective serotonin2-receptor blocker) with dihydralazine in the management of severe early-onset hypertension in pregnancy. ⋯ The antihypertensive profile of ketanserin is characterised by an early and gradual reduction of blood pressure in combination with a moderate decrease in systemic vascular resistance and no significant change in cardiac output. Dihydralazine causes market tachycardia resulting in a considerable increase in cardiac output.
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Br J Obstet Gynaecol · Jul 1998
Randomized Controlled Trial Clinical TrialPuerperal thromboprophylaxis: comparison of the anti-Xa activity of enoxaparin and unfractionated heparin.
Low molecular weight heparins are used extensively for thromboprophylaxis. The aim of this study was to compare the activity of the low molecular weight heparin, enoxaparin, 20 mg and 40 mg, given once per day with unfractionated heparin, 7500iu given twice per day, in terms of their anti-Xa activity in puerperal women following caesarean section and with an additional risk factor for venous thromboembolism. Seventeen women were randomised to receive one of the three treatments. ⋯ The mean anti-Xa values of the groups receiving enoxaparin, 20 mg and 40 mg, were significantly higher than those of the group receiving unfractionated heparin. There was no difference between the two enoxaparin groups in terms of the anti-Xa activity profiles. This study suggests that the use of enoxaparin is superior to unfractionated heparin in terms of anti-Xa activity.
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Br J Obstet Gynaecol · Mar 1998
Randomized Controlled Trial Clinical TrialA randomised controlled trial of intravenous magnesium sulphate versus placebo in the management of women with severe pre-eclampsia.
To determine whether the administration of prophylactic intravenous magnesium sulphate reduces the occurrence of eclampsia in women with severe pre-eclampsia. ⋯ The use of intravenous magnesium sulphate in the management of women with severe pre-eclampsia significantly reduced the development of eclampsia.
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Br J Obstet Gynaecol · Mar 1998
Randomized Controlled Trial Clinical TrialBarbados Low Dose Aspirin Study in Pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications.
To determine whether prophylactic, low dose controlled-release aspirin improves outcome for pregnant women and their babies in Barbados. ⋯ The results of this study in Barbados do not support the routine use of low dose aspirin for prevention of pre-eclampsia or its complications, confirming results of previous large trials in other settings.