Romanian journal of internal medicine = Revue roumaine de médecine interne
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Randomized Controlled Trial Comparative Study Clinical Trial
The effect of metoclopramide on antral emptying of a semisolid meal in patients with functional dyspepsia. A randomized placebo controlled sonographic study.
The aim of this study was to investigate the effect of metoclopramide on the antral emptying of a semisolid meal. Twenty-five patients with functional dyspepsia received in a prospective randomized trial either metoclopramide 10 mg t.i.d. (n = 14) or placebo (n = 11) for 7 days. The antral emptying was measured by real-time ultrasound with a 3.5 MHz probe from the antral area recordings in the aorto-mesenteric plane. ⋯ Antral emptying was accelerated by metoclopramide compared with placebo. Fasting antral emptying was not changed by metoclopramide and the postprandial antral area had a trend to decrease. These data suggest that the effect of metoclopramide is less due to the enhancement of antral motility but rather to the reduction of postprandial fundus relaxation.