Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Nov 2007
[Change of N-terminal pro-brain natriuretic peptide and big endothelin in patients undergoing coronary artery bypass grafting].
To examine the change in N-terminal pro-brain natriuretic peptide (Nt-proBNP) and big endothelin (big ET) in patients undergoing coronary artery bypass grafting (CABG), and to evaluate their value in predicting postoperative mortality and complication. ⋯ Significant increase in Nt-proBNP and ET is found after CABG. BNP and LVEF are showed to be risk factors for postoperative complications in patients undergoing CABG.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Nov 2007
[Expression of tumor necrosis factor-alpha in myocardium and dorsal root ganglion of coronary artery occlusion in rats].
To observe the temporal expression of tumor necrosis factor-alpha (TNF-alpha) in myocardium and dorsal root ganglion (DRG) following ligation of the left anterior descending branch of coronary artery in the rats, and to explore the potential role of TNF-alpha in the neurogenic mechanisms induced by myocardial ischemia injury and the potential neurogenic mechanisms of acute local myocardial ischemia provoking global injuries of the heart. ⋯ CAO can provoke a significant increase in TNF-alpha and TNF-alpha mRNA in the myocardium (ischemic and non-ischemic) and DRG of rats. It demonstrates that acute myocardial ischemia, as a nociceptive stimulus, may activate the neurogenic reactions in body, and TNF-alpha might play an important role in the whole process, while the neurogenic mechanisms may contribute to the development of myocardial injury.