Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[Changes in expressions of the myocardial Toll-like receptor 4, tumor necrosis factor-alpha and interleukin-6 mRNA in rat with sepsis].
To investigate the relationship between apoptosis of myocardial cell in the rats with sepsis and the expressions of Toll-like receptor 4 (TLR4), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) mRNA, and the protective effect of glutamine (Gln) against apoptosis of myocardial cell. ⋯ TLR4, TNF-alpha and IL-6 gene expressions play extremely important role in apoptosis of myocardial cell in the rat with sepsis. Gln can affect apoptosis-related gene expressions, thus alleviating the apoptosis of myocardial cell.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[Role of macrophage migration inhibitory factor in mice with sepsis and after effect of its intervention].
To investigate the expression profile of macrophage migration inhibitory factor (MIF) in serum and lung tissues of mice with sepsis, and to explore the effect of MIF antagonist ISO-1 on sepsis in a murine sepsis model. ⋯ MIF plays a role as a late mediator in sepsis, with a high expression of MIF in serum and lung tissue. ISO-1 can elevate the surviving rate in murine model of sepsis. It is concluded that MIF could be taken as a potential target of treatment of sepsis.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[An evaluation of stroke volume variation as a predictor of fluid responsiveness in mechanically ventilated elderly patients with severe sepsis].
To evaluate stroke volume variation (SVV) as a predictor of fluid responsiveness in mechanically ventilated (MV) elderly patients with severe sepsis. ⋯ Functional hemodynamic parameter SVV can predict fluid responsiveness in elderly MV patients with severe sepsis during fluid resuscitation, it may serve as a useful index for guiding fluid therapy in elderly patients with severe sepsis.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[The effect of blood glucose fluctuations on prognosis of critically ill patients in intensive care unit].
To determine the association between glucose fluctuations and hospital mortality in intensive care unit (ICU) patients. ⋯ The increase in GluSD and GluCV in critically ill patients is significantly correlated with ICU mortality and hospital mortality, and they are more valuable in predicting ICU mortality than GluAdm, GluAve. Diminution in fluctuation of blood glucose might be an important aspect of glucose management.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[The application of disseminated intravascular coagulation score in sepsis].
To study the relationship between the disseminated intravascular coagulation (DIC) score and assessment of illness and prognosis in sepsis. ⋯ APACHE II score and DIC score can be used as the prognostic factors of sepsis, but the value of DIC score was lower than APACHE II score in diagnosis and prognosis of sepsis.