Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Sep 2009
Randomized Controlled Trial Multicenter Study[The preemptive treatment of invasive Candida infection with reference of corrected colonization index in critically ill patients: a multicenter, prospective, randomized controlled clinical study].
To evaluate preemptive treatment for invasive Candida infection (ICI) with reference of corrected colonization index (CCI) in critically ill patients with high risk factors of Candida infection, and to collect the epidemiology data of Candida infection. ⋯ Application of CCI may enhance the accuracy of timely preemptive treatment for ICI, and facilitate the collection of epidemiological data of Candida in critically ill patients.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Sep 2009
Randomized Controlled Trial[The effect of low-dose hydrocortisone on requirement of norepinephrine and lactate clearance in patients with refractory septic shock].
To observe the effect of low-dose hydrocortisone on the requirement of norepinephrine and lactate clearance in patients with refractory septic shock, and to investigate the effect of stress dose corticosteroids in reversing septic shock and improving tissue oxygen supply. ⋯ For the patients with septic shock with refractory hypotension, low-dose hydrocortisone can decrease the time course and dosage of vasopressors, improve tissue oxygen supply, thus can reverse septic shock more rapidly.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[A study of urine lactulose/mannitol ratio and intestinal fatty acid binding protein as the indexes of intestinal damage in sepsis].
To assess urine lactulose/mannitol ratio (LMR), and intestinal fatty acid binding protein (IFABP) concentration as the indexes of intestinal damage in septic patients, and to evaluate the clinical severity and mortality of septic patients by use of these indexes. ⋯ This study reveals that patients with sepsis have intestinal mucosal damage and increased intestinal permeability. Increased LMR in urine is associated with clinical severity and prognosis; urine IFABP concentration is not associated with clinical severity and prognosis. Patients with stress ulcer have higher urine IFABP concentration. There is no correlation among IFABP, LMR and gastrointestinal function score.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Aug 2009
[Role of macrophage migration inhibitory factor in mice with sepsis and after effect of its intervention].
To investigate the expression profile of macrophage migration inhibitory factor (MIF) in serum and lung tissues of mice with sepsis, and to explore the effect of MIF antagonist ISO-1 on sepsis in a murine sepsis model. ⋯ MIF plays a role as a late mediator in sepsis, with a high expression of MIF in serum and lung tissue. ISO-1 can elevate the surviving rate in murine model of sepsis. It is concluded that MIF could be taken as a potential target of treatment of sepsis.