Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Feb 2007
[Effects of mechanical ventilation on the expression of Toll like receptor 4 in rat's alveolar macrophages].
To investigate the effects of mechanical ventilation on Toll like receptor 4 (TLR4) in rat's alveolar macrophages (AM). ⋯ Large V(T) mechanical ventilation induced injury of lungs and up-regulated TLR4 expression in rat's AM. Small V(T) mechanical ventilation avoided above-mentioned changes.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2007
[Apoptosis of circulating lymphocyte in surgical critically ill patients associated with poor outcome].
To investigate the role and mechanism of lymphocyte apoptosis in post-operative critically ill patients and to determine the effects of lymphocyte apoptosis on the outcome of post-operative critically ill patients. ⋯ Lymphocyte apoptosis is enhanced in peripheral blood of post-operative critically ill patients and leads to a profound and persistent lymphopenia associated with poor outcome such as secondary infection and delay of ICU stay duration. Further studies are required to examine whether intervention to prevent lymphocyte apoptosis might alter the patients' outcome.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2007
[Value of monitoring oxygen metabolism in multiple organ dysfunction syndrome after severe trauma].
To study changes in oxygen metabolism and evaluate metabolic status in tissue and cell after severe trauma, and to investigate value of monitoring oxygen metabolism in the course of development of multiple organ dysfunction syndrome (MODS) in trauma between patients. ⋯ Changes in level of oxygen metabolism might be closely correlated with development of MODS in trauma patients. Dynamic monitorings of metabolic status of tissue and cell are valuable in predicting the development of MODS after severe trauma.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2007
[Clinical evaluation of execution of early goal directed therapy in septic shock].
To evaluate the efficacy of early goal directed therapy (EGDT) in septic shock. ⋯ In the earlier period of septic shock, EGDT can remarkably decrease the patients'mortality and incidence of organ dysfunction, but can not improve survival rate and prognosis in patients in advanced stage of septic shock.
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Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Jan 2007
[Reproduction of a rat model of disseminated intravascular coagulation accompanied by multiple organ injuries].
To reproduce a rat model of disseminated intravascular coagulation (DIC) accompanied by multiple organ dysfunction syndrome (MODS) induced by endotoxin. ⋯ Double intravenous LPS challenge (98 microg/kg and 196 microg/kg) in rats can reproduce a rat model with DIC accompanied by multiple organ injuries.