Journal of toxicology. Clinical toxicology
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J. Toxicol. Clin. Toxicol. · Jan 1998
The effects of 4-aminopyridine and Bay K 8644 on verapamil-induced cardiovascular toxicity in anesthetized rats.
To determine the effects of 4-aminopyridine and Bay K 8644 on mean arterial pressure and heart rate in an anesthetized rat model of verapamil toxicity. ⋯ 4-Aminopyridine improved mean arterial pressure and heart rate in a dose-dependent fashion; however, the higher infusion rate (2 mg/kg/h) necessary to improve mean arterial pressure and heart rate resulted in convulsions and excessive secretions. The reversal effects of Bay K 8644 on mean arterial pressure were transient and did not affect heart rate.
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J. Toxicol. Clin. Toxicol. · Jan 1998
Case ReportsAcute cerebral gas embolism from hydrogen peroxide ingestion successfully treated with hyperbaric oxygen.
We present a case of an adult who suffered an apparent stroke shortly after an accidental ingestion of concentrated hydrogen peroxide. Complete neurologic recovery occurred quickly with hyperbaric therapy. ⋯ Hyperbaric therapy is the definitive treatment for gas embolism from hydrogen peroxide ingestion as it is for all other causes of acute gas embolism. This is the first case reported in the literature of hyperbaric therapy used successfully to treat cerebral gas embolism caused by hydrogen peroxide.
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An accidental exposure due to reuse of containers of toluene diisocyanate to transport nontoxic substances and subsequent occupational toxic exposure caused illness among forty workers in a glove manufacturing plant. Examination and investigation of the patients and factory site inspection were carried out. ⋯ Thirty-two of forty patients had muscle pain and seven had elevated creatine phosphokinase activity. These features have not been reported previously as components of toluene diisocyanate toxicity and their underlying causation remains speculative.