Journal of toxicology. Clinical toxicology
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J. Toxicol. Clin. Toxicol. · Jan 2000
The effect of sodium bicarbonate on propranolol-induced cardiovascular toxicity in a canine model.
To evaluate the potential utility of sodium bicarbonate in an established model of acute propranolol toxicity. ⋯ In this canine model of propranolol toxicity, intravenous sodium bicarbonate appears to be an ineffective single therapy. Furthermore, these results may suggest a different mechanism of sodium channel blockade for propanolol than that of type IA antiarrhythmic agents.