Journal of toxicology. Clinical toxicology
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J. Toxicol. Clin. Toxicol. · Jan 1998
Case ReportsProlonged formation of methemoglobin following nitroethane ingestion.
Artificial nail removers containing nitroethane pose a serious risk of toxicity when ingested. ⋯ We report 3 cases of children under 3 years of age who developed prolonged methemoglobinemia following ingestions of small quantities of these nitroethane-containing products. Methylene blue therapy reduced the methemoglobin level in all 3 children; however, in 2 of these children methemoglobin levels increased again several hours later and required additional methylene blue. Accurate substance identification is essential for appropriate management of ingestions of fingernail products. The availability of nitroethane products for home use should be questioned.
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J. Toxicol. Clin. Toxicol. · Jan 1998
Review Case ReportsFatality resulting from intraventricular vincristine administration.
Inadvertent intrathecal administration of vincristine has been reported and is uniformly fatal except in two of three cases treated with spinal fluid exchange. We report a case of inadvertent direct intraventricular vincristine administration. ⋯ Despite aggressive and immediate therapy, intraventricular vincristine infusion produced neurologic toxicity, with progressive loss of mental function, followed by coma and death. Systems need to be developed to prevent inadvertent central nervous system administrations.
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J. Toxicol. Clin. Toxicol. · Jan 1998
Case ReportsECG conduction delays associated with massive bupropion overdose.
Bupropion, a relatively new antidepressant, is highly regarded for its safety profile in therapeutic doses and in the overdose. Seizure is the primary adverse reaction associated with bupropion overdoses. Clinically significant cardiovascular complications are rare. ⋯ We report the case of an adult male who ingested 9 g bupropion and developed neurologic toxicity as well as intraventricular conduction disturbances on electrocardiogram. Cardiac monitoring of these patients should be considered.
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J. Toxicol. Clin. Toxicol. · Jan 1998
Case ReportsAcute cerebral gas embolism from hydrogen peroxide ingestion successfully treated with hyperbaric oxygen.
We present a case of an adult who suffered an apparent stroke shortly after an accidental ingestion of concentrated hydrogen peroxide. Complete neurologic recovery occurred quickly with hyperbaric therapy. ⋯ Hyperbaric therapy is the definitive treatment for gas embolism from hydrogen peroxide ingestion as it is for all other causes of acute gas embolism. This is the first case reported in the literature of hyperbaric therapy used successfully to treat cerebral gas embolism caused by hydrogen peroxide.