Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Oct 2019
Comparative StudyImmunosuppressive treatment with everolimus in patients after liver transplant: 4 years of single-center experience.
Everolimus after liver transplant (LT) has been used to minimize the use of calcineurin inhibitors (CNIs), optimize renal function, and prevent recurre nce of hepatocellular carcinoma (HCC). ⋯ This study showed that switching from CNIs to everolimus after LT allowed a safe weaning of CNIs and an improvement in creatinine levels. In patients on everolimus monotherapy, we observed dyslipidemia as a dose‑dependent side effect of the drug as well as a lower risk of HCC recurrence.
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Pol. Arch. Med. Wewn. · Oct 2019
Polypharmacy and medication errors on admission to palliative care.
Many patients at the end of their life are treated with multiple medications while some of the drugs may no longer be beneficial and should be reduced. ⋯ Polypharmacy and increased risk of drug inappropriateness particularly affect elderly patients referred by hospitals, with poor prognosis, low performance, admitted to in‑patient hospice. Therapy reduction may diminish the risk of therapeutic inappropriateness but requires further education within nonspecialist palliative care.