Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Sep 2020
Diffusion-weighted magnetic resonance enterocolonography in assessing Crohn's disease activity.
Diffusion‑weighted magnetic resonance imaging has the potential to identify inflamed bowel segments in patients with Crohn disease (CD). ⋯ DWI is a valuable tool that is capable of identifying inflamed bowel segments as accurately as the conventional MaRIA score and of discriminating between mild and moderate-to-severe CD.
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Pol. Arch. Med. Wewn. · Sep 2020
ReviewInvestigations and management of chronic cough: update from the European Respiratory Society Chronic Cough Taskforce 2020.
Chronic cough affects approximately 10% of the general population, is highest amongst people aged 50 to 60 years, and is twice as common in women than men. It is described to last 8 weeks or longer in adults and does not respond well to treatment with over-the-counter medications and those targeting potential associated conditions. This is a debilitating condition with physical, social, and psychological consequences. ⋯ In some cases, no cause can be found and the cough is classified as unexplained chronic cough. If treatment of any underlying disease is unsuccessful at controlling cough, then neuromodulatory treatment such as a low‑dose opioid, gabapentin, pregabalin or speech and language therapy may be considered. There is no licensed treatment for chronic cough, but a new class of treatment targeting the purinergic P2X3 receptor is currently in phase 2 and 3 of development.
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Pol. Arch. Med. Wewn. · Sep 2020
The association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and the plasma fibrinogen level in women and men with premature coronary artery atherosclerosis.
The insertion/deletion (I/D) polymorphism of the angiotensin‑converting enzyme (ACE) gene is associated with younger age at coronary artery disease (CAD) onset. Some data indicate the relationship between the DD genotype and the fibrinogen level. At the same time, the regulation of the renin-angiotensin system differs in women and men. ⋯ The DD genotype of the ACE gene was associated with higher plasma fibrinogen levels in women with premature CAD yet not in men.