Polskie Archiwum Medycyny Wewnętrznej
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Pol. Arch. Med. Wewn. · Dec 2021
Thyroid nodules with indeterminate cytopathology: a constant challenge in everyday practice. The effectiveness of clinical decisions using diagnostic tools available in Poland.
A crucial issue in the management of thyroid nodules is an accurate estimation of their malignancy risk. The key tool for risk stratification is fine-needle aspiration biopsy. Unfortunately, approximately 20% of biopsy results are indeterminate. The malignancy risk assigned to these categories does not allow unequivocal further management. ⋯ The majority of Polish patients with thyroid nodules assigned to Bethesda III and IV cytological categories are overtreated based on the use of diagnostic tools currently available in Poland.
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Pol. Arch. Med. Wewn. · Dec 2021
Multicenter StudyPatterns of multimorbidity in 4588 older adults. Implications for non-geriatrician specialist.
Multimorbidity has been recognized as an important factor in geriatric medicine. However, its importance for other specialists is still to be fully appreciated. ⋯ The age-specific analysis of clustering revealed differences in prevalence and patterns of comorbidities, which stresses the importance of individual approach to older patients.
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Pol. Arch. Med. Wewn. · Dec 2021
Cholesterol homeostasis is dysregulated in women with preeclampsia.
The link between preeclampsia and dyslipidemia has been established. Even though lipid profile parameters have been intensively investigated in the pathology of preeclampsia, their accurate molecular mechanisms of action have not been fully decoded. ⋯ Late-onset preeclampsia could be associated with an altered lipid profile. By studying the quantitative metabolic signatures of cholesterol, we might assume that both cholesterol synthesis and absorption are increased, that is, there is an imbalance in the cholesterol homeostasis regulation in women affected by the disease.