Recenti progressi in medicina
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Multicenter Study Comparative Study Observational Study
Safety and effectiveness of direct oral anticoagulants versus vitamin K antagonists: results from 3 Italian regions.
In Italy, direct oral anticoagulant drugs (DOACs) were authorized for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) in 2013. There is conflicting evidence on their benefit-risk profile under real world conditions. ⋯ The present study confirms findings from previous research regarding bleeding events, whereas we did not find a reduced risk of mortality in DOAC users. Further research on single active agents and specific populations is warranted.