Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
-
Pol. Merkur. Lekarski · Apr 2002
Randomized Controlled Trial Clinical Trial[Captopril in the treatment of acute myocardial infarction. Hypotension as an important clinical problem].
The aim of study was to analyze the effect of captopril (C) on blood pressure in patients with acute myocardial infarction (AMI) during 1 year treatment. Patients less then 70 years old with systolic blood pressure (sBP) > or = 100 mm Hg were qualified to the study. Administration of C was started during the first 4 days of AMI (mean 21 +/- 24 h). 50 pts treated with C and control group of 43 pts were finally analyzed. ⋯ In conclusion, hypotension seems to be quite often encountered during captopril therapy of early phase of AMI. It appears not only after the first but also after the following doses. The initial dose of 3.125 mg seems to be safe and sufficient to assess its hypotensive action.