European review for medical and pharmacological sciences
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Eur Rev Med Pharmacol Sci · Jan 2014
Study on plasmatic metabolomics of Uygur patients with essential hypertension based on nuclear magnetic resonance technique.
Metabolomics is the analysis of the global constitution of endogenous metabolites in cells, tissue, and bodily fluids based on analysis techniques with high output, high sensitivity, and high resolution. The physiological and pathological state of the subject investigated could be identified and analyzed through examining metabolite changes. In this study, 1H-NMR metabolomics was employed to study plasma metabolites of both Uygur patients with hypertension and healthy people, thereby filtering out characteristic metabolites for Uygur patients with hypertension. The pathogenesis of hypertension was discussed via metabolic pathways. ⋯ The 1H-NMR metabolomics process, in combination with OPLS-DA pattern identification, is an effective way to differentiate the serum metabolites characteristic of hypertension patients. Pattern identification analysis of NMR spectrum data with OPLS-DA could identify metabolites of hypertension patients versus healthy subjects. The metabolic phenotype of Uygur hypertension patients shows significant heteromorphosis, with the 12 characteristic metabolites as potential biomarkers of hypertension.
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Eur Rev Med Pharmacol Sci · Jan 2014
Case ReportsTwo cases of Brown-Séquard syndrome in penetrating spinal cord injuries.
Brown-Séquard syndrome due to a stab injuries is uncommon and results from a lesion in one half of the spinal cord. ⋯ As the neurologic improvement depends on the type and severity of the spinal cord damage, the indications for acute surgical management are limited and conservative management should be preferred.
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Eur Rev Med Pharmacol Sci · Jan 2014
Randomized Controlled Trial Comparative StudyClinical comparative analysis on unstable pelvic fractures in the treatment with percutaneous sacroiliac screws and sacroiliac joint anterior plate fixation.
To investigate clinical efficacy of unstable pelvic fractures in the treatment with percutaneous sacroiliac screws and sacroiliac joint anterior plate fixation. ⋯ Percutaneous sacroiliac screw internal fixation in the treatment of unstable pelvic fractures has less injury, less bleeding, less pain and rapid recovery which is a safe and effective minimally invasive operation method. The clinical curative effect of percutaneous sacroiliac screw internal fixation is better than anterior plate fixation for the treatment of sacroiliac joint. The full preparation before the surgery and patients with positive can substantially reduce the occurrence of complications rate.
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Eur Rev Med Pharmacol Sci · Jan 2014
ReviewMechanical thrombectomy with Solitaire stent for acute internal carotid artery occlusion without atherosclerotic stenosis: dissection or cardiogenic thromboembolism.
In acute ischemic stroke patients, internal carotid artery occlusion with middle cerebral artery (ICA/MCA) occlusion in succession predicts a poor outcome after systemic thrombolysis. It is not known whether this occlusion subtype of the anterior circulation is due to dissections or cardiogenic thromboembolism. We aimed to find useful evidence to judge the condition with accuracy and establish reasonable treatment protocols. ⋯ Our results and the literature review suggest that mechanical thrombectomy in acute stroke due to ICA/MCA occlusion is feasible and safe, with high rates of recanalization and favorable functional outcomes. More patients with ICA/MCA occlusion in succession could obtain favorable functional outcomes with accurate judgment of the lesion location and appropriate treatment protocols. However, there is no consensus on how to judge the correct location of the ICA dissected portion and whether stenting is appropriate.
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Eur Rev Med Pharmacol Sci · Jan 2014
Meta Analysis Comparative StudyTraditional coronary artery bypass graft versus totally endoscopic coronary artery bypass graft or robot-assisted coronary artery bypass graft--meta-analysis of 16 studies.
Robot-assisted coronary artery bypass graft (RACAB) or totally endoscopic coronary artery bypass graft (TECAB) utilizing the da Vinci surgical system is increasingly used to treat coronary heart disease (CHD), although traditional coronary artery bypass graft (CABG) remains a classic treatment. The aim of the present study was to establish the advantages and disadvantages of TECAB (or RACAB) compared with traditional CABG. ⋯ TECAB and RACAB are safe and feasible therapies for CHD. This meta-analysis supports TECAB(or RACAB)using the da Vinci surgical system to treat CHD with reduced MACCE after 12 months. In addition, TECAB and RACAB do not increase the rates of MACCE in hospital, graft stenosis (or occlusion), and the need for reintervention compared with CABG.