Regional anesthesia
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Regional anesthesia · Jan 1995
Randomized Controlled Trial Clinical TrialContinuous high thoracic epidural administration of morphine with bupivacaine after thoracotomy.
The purpose of the study is to determine the ideal concentration of morphine when given with bupivacaine as a continuous high thoracic epidural infusion for postthoracotomy pain. ⋯ Continuous high thoracic epidural administration 0.2 mg/mL morphine in bupivacaine 0.75% at an infusion rate of 0.8 mL/hr with a loading dose of 1 mg morphine is an effective dose for postthoracotomy pain relief in rest, and more important, during exercise.
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Regional anesthesia · Jan 1995
Randomized Controlled Trial Clinical TrialAddition of clonidine to epidural morphine enhances postoperative analgesia after cesarean delivery.
The randomized, double-blind, dose-response study was designed to evaluate the effects of the addition of clonidine to epidural morphine on postoperative analgesia and side effects in patients undergoing cesarean delivery. ⋯ A low dose of clonidine such as 75 micrograms doubled the duration of analgesia produced by 2 mg of morphine and a dose of 150 micrograms further increased the duration of postoperative complete analgesia without increasing the incidence of side effects. The morphine requirements during the postoperative period (36 hours) was greatly reduced by the addition of clonidine to the analgesic epidural mixture.