Regional anesthesia
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Regional anesthesia · May 1995
Randomized Controlled Trial Comparative Study Clinical TrialAging reduces the reliability of epidural epinephrine test doses.
The authors recently determined that intravascular injection of an epinephrine test dose reliably produced an increase in heart rate > or = 20 beats/min in young individuals. However, aging is associated with a significant reduction in beta-adrenergic responsiveness. This study was designed to determine whether aging decreases the magnitude of heart rate (HR) increase after intravascular injection of epinephrine. ⋯ Aging is associated with a reduction in the magnitude of HR increase after intravenous injection of epinephrine. The results suggest that to detect an intravascular injection in healthy people, a test dose containing 10 micrograms epinephrine will suffice before the age of 40. However, even 15 micrograms epinephrine will not be totally reliable in older patients, owing to decreased beta-adrenergic responsiveness.
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Regional anesthesia · May 1995
Randomized Controlled Trial Comparative Study Clinical TrialEffect of anesthetic technique on acute formalin-induced pain in mice.
The aim of this study was to determine if anesthetic technique influences the degree of acute formalin-induced pain in mice. ⋯ The administration of a pre-emptive subarachnoid lidocaine block in the combined spinal/general anesthesia group did not reduce the degree of formalin-induced paw-licking behavior. Combined spinal/general anesthesia did not decrease acute formalin-induced pain in mice.