Przegla̧d lekarski
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The bronchial obturation reversibility test is the corner stone in asthma diagnosis. Patients with signs and symptoms suggestive of asthma but normal spirometry need additional tests like non-specific bronchoprovocations. Exercise-induced bronchi spasm is a feature of asthma and is the basis for exercise-test bronchi provocation in asthma diagnosis. The aim of this study was the comparison of clinical utility of obturation reversibility test and exercise provocation test in asthma diagnosis in patients with normal spirometry values. ⋯ 1. Exercise test is a valuable diagnostic tool in patients with history suggestive of asthma and normal spirometry results and negative obturation reversibility test. 2. The parameter for the exercise test that best separate asthma and control group was FEV1.
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Clinical Trial
[Mycophenolate mofetil in treatment of childhood nephrotic syndrome--preliminary report].
The management of nephrotic syndrome (NS) in children remains a clinical challenge for pediatricians and pediatric nephrologists. Especially, the treatment of patients with steroid-resistant (SR) and steroid-dependent (SD) nephrotic syndrome, because they are at risk for developing complications from prolonged exposure to steroids, CsA and alkylating agents. Mycophenolate mofetil (MMF) is a selective and reversible inhibitor of inosine monophosphate dehydrogenase used above all in transplantology and recently also in patients with nephrotic syndrome. ⋯ The initial clinical observation of MMF treatment in nephrotic patients shows its best effect in the group of patients with steroid-dependent NS. MMF can safely be used in children with NS. The introduction of MMF allows for reduction of other chronically used medications, especially CsA and steroids.
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Comparative Study
[Antibodies against heat shock proteins (HSP) in children with chronic renal failure (CRF)--preliminary results].
Current data suggest the role of autoimmune reactions in the pathogenesis of cardiovascular complications in CRF patients. Elevated levels of anti-Hsp autoantibodies (anti-Hsp60, anti-Hsp70) have been described in adults with atherosclerotic lesions and cardiovascular events. The aim of the study was to evaluate the levels of anti-Hsp60 and anti-Hsp70 in sera of CRF children. Serum uric acid, lipid profile, erythrocyte sedimentation rate (ESR) and hsCRP were also estimated. ⋯ Preliminary results point at relations between anti-Hsp70, markers of chronic inflammation (ESR) and atherosclerotic risk (uric acid, cholesterol) in CRF children.
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Comparative Study
[Assessment of chosen cognitive functions in children and adolescents with primary headaches].
Foundations and aim of the study: Right development of cognitive functions is one of the basal factors, which determines good realization of the developmental tasks, for example achievement in education. Primary headaches especially migraine can be one of the important factor disturbing cognitive functioning of children and adolescents. The aim of the study was to estimate the level of some chosen aspects of cognitive and intellectual functioning of children and adolescents with primary headaches: migraine and tension type (TTH). ⋯ Patients with migraine in comparison to children with TTH show important disturbances in ability of short-term visual memory and visuomotor integration. Diagnosed selected cognitive dysfunctions in children with primary headaches can disturb accomplishment of tasks connected with education but they do not have any important influence on general intellectual functioning.
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Lyme borreliosis is caused by the spirochete Borrelia burgdorferi, which is transmitted into the human body by ticks. The clinical symptoms are associated with skin, joints, heart and nervous system. Four groups of antibiotics are used in Lyme borreliosis treatment: penicillins, cephalosporins, tetracyclines and macrolides. We present the case of Lyme borreliosis with outbreak joint manifestation.