Research in veterinary science
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Comparative Study
A pharmacodynamic study of propofol or propofol and ketamine infusions in ponies undergoing surgery.
The pharmacodynamics of infusions of propofol alone (group 1) were compared with the pharmacodynamics of infusions of propofol and ketamine together (group 2) in eight ponies undergoing castration. Anaesthesia was induced with detomidine, 20 micrograms kg-1, followed by ketamine, 2.2 mg kg-1. ⋯ Arterial hypotension and marked respiratory depression were evident in some of the ponies receiving propofol alone, whereas in the ponies anaesthetised with propofol and ketamine, respiratory and cardiovascular parameters were well maintained. All the ponies in both groups recovered quickly from anaesthesia, with mean times to sternal recumbency and standing of 19.8 (8.0) minutes and 27.2 (7.4) minutes respectively for group 1 and 8.4 (3.2) min and 14.9 (10.1) minutes for group 2.