Research in veterinary science
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Comparative Study
Neuromuscular blocking action of atracurium in the dog and its reversal by neostigmine.
The drug, atracurium besylate is one of a new series of competitive muscle relaxants. Doses of 0.2, 0.4 and 0.6 mg/kg produced neuromuscular block in the anaesthetised dog with no cardiovascular effects. The neuromuscular block was readily reversible by neostigmine.
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A technique is described for assessing the extent of residual neuromuscular block following non-depolarising agents in the dog. The ulnar nerve was electrically stimulated with a train-of-four impulses and the muscle responses recorded. ⋯ There was a highly significant linear correlation between the ratio T1/control, used to determine the extent of neuromuscular block, and the other ratios T2/T1 and T4/T1. Both of the ratios T2/T1 and T4/T1 avoid the use of control heights.