Casopís lékar̆ů c̆eských
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Fibromyalgia is a chronic syndrome characterized by dysfunction of pain processing and regulation. Although the definite etiology has not been recognized yet, the key role in the pathogenesis of this syndrome probably plays the central sensitization process with the development of chronic (central) pain and other associated symptoms (fatigue, stiffness, sleep disorders, cognitive and vegetative disturbance). ⋯ New drugs introduced to the therapy in the recent years can have positive effect on symptom reduction and improvement of patients quality of life. Key words: fibromyalgia, chronic pain, fatigue, central sensitization.