The lancet. Diabetes & endocrinology
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Lancet Diabetes Endocrinol · Aug 2015
Randomized Controlled Trial Clinical TrialEffect of metformin pretreatment on myocardial injury during coronary artery bypass surgery in patients without diabetes (MetCAB): a double-blind, randomised controlled trial.
During coronary artery bypass graft (CABG) surgery, ischaemia and reperfusion damage myocardial tissue, and increased postoperative plasma troponin concentration is associated with a worse outcome. We investigated whether metformin pretreatment limits cardiac injury, assessed by troponin concentrations, during CABG surgery in patients without diabetes. ⋯ Netherlands Organisation for Health Research and Development and Netherlands Heart Foundation.
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Lancet Diabetes Endocrinol · Aug 2015
Randomized Controlled Trial Clinical TrialOutpatient overnight glucose control with dual-hormone artificial pancreas, single-hormone artificial pancreas, or conventional insulin pump therapy in children and adolescents with type 1 diabetes: an open-label, randomised controlled trial.
Additional benefits of the dual-hormone (insulin and glucagon) artificial pancreas compared with the single-hormone (insulin alone) artificial pancreas have not been assessed in young people in outpatient unrestricted conditions. We evaluated the efficacy of three systems for nocturnal glucose control in children and adolescents with type 1 diabetes. ⋯ Canadian Diabetes Association, Fondation J A De Sève.