The lancet. Diabetes & endocrinology

The most recent articles from: Lancet Diabetes Endocrinol February 2016

Lancet Diabetes Endocrinol · Feb 2016

Randomized Controlled Trial Comparative Study

Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.

Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a potassium-sparing diuretic, amiloride, to treatment with a thiazide can prevent glucose intolerance and improve blood pressure control. ⋯ British Heart Foundation and National Institute for Health Research.

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