The lancet. Diabetes & endocrinology
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Lancet Diabetes Endocrinol · Sep 2018
Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study.
Although some cardiovascular disease prevention guidelines suggest a need to manage work stress in patients with established cardiometabolic disease, the evidence base for this recommendation is weak. We sought to clarify the status of stress as a risk factor in cardiometabolic disease by investigating the associations between work stress and mortality in men and women with and without pre-existing cardiometabolic disease. ⋯ NordForsk, UK Medical Research Council, and Academy of Finland.
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Lancet Diabetes Endocrinol · Sep 2018
Randomized Controlled Trial Multicenter StudyCanagliflozin and renal outcomes in type 2 diabetes: results from the CANVAS Program randomised clinical trials.
In the Canagliflozin Cardiovascular Assessment Study (CANVAS) Program, canagliflozin reduced the rates of major adverse cardiovascular events and the results suggested a renal benefit in patients with type 2 diabetes who were at high risk for cardiovascular events, compared with those treated with placebo. Here we report the results of a prespecified exploratory analysis of the long-term effects of canagliflozin on a range of sustained and adjudicated renal outcomes. ⋯ Janssen Research & Development.