Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
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Evidence-based medicine combines the patient's preferences with clinical experience and the best research evidence. Randomized clinical trials are considered the most valid research design for evaluating health-care interventions. However, empirical research shows that intervention effects may be significantly overestimated (in one study on average by about 50 per cent) in randomized clinical trials with inadequate methods for generation of allocation sequence, allocation concealment, and double blinding. ⋯ Accordingly, there is an urgent need to improve this situation. Guidelines for Good Clinical (Research) Practice, conduct of more trials as multicentre trials, The Consort Statement, and The Cochrane Collaboration may all help in the application of the best research evidence in clinical practice. By investments in education, applied research, and The Cochrane Collaboration, evidence-based medicine may form a stronger basis for clinical practice.