Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
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Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Apr 2021
Review[Research Progress on Role and Mechanism of Elabela in Organ Fibrosis].
Elabela is a newly discovered peptide in recent years. It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs. Elabela-APJ axis is closely related to organ fibrosis. ⋯ In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors. However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis. This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.