Revista medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti din Iaş̧i
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Rev Med Chir Soc Med Nat Iasi · Oct 2013
Metformin induced lactic acidosis--particularities and course.
Diabetes mellitus is a widespread disease with many serious chronic complications. An improvement in the oral antidiabetic medication in respect to its mechanism of action and toxicology was needed in order to have effective therapies with high compliance and minimum side effects. In this context, metformin is a widely used oral antidiabetic drug, which, through its mechanism of action, has no risk of hypoglycemia. ⋯ This paper presents a number of 13 cases of metformin-associated lactic acidosis, which outline the circumstances triggering the adverse event and the clinical therapeutic measures applied in the poisoned patients. The main situations that favor metformin-associated lactic acidosis are renal impairment and tissue hypoxia, and the intervention is adapted to the particular patient condition and symptoms, such as marked hypotension and cardiac arrest. Although there are commonalities in describing the consulted patients, the final prognosis is not dependent on the dose or metformin plasma levels, but rather on the associated pathologies and medication.
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Rev Med Chir Soc Med Nat Iasi · Jul 2013
Risk assessment in the development of atrial fibrillation at patients with associate thyroid dysfunctions.
Thyroid hormones are an important regulator of cardiac function and vascular system. Atrial fibrillation is a common cardiac arrhythmia and an important risk factor for the ischemic cerebral vascular accident and heart failure. ⋯ Thyroid dysfunctions are associated with an increased risk to develop atrial fibrillation, both in the case of clinically manifest and the subclinical manifest forms. These results support long term screening for thyroid dysfunctions for patients with atrial fibrillation.
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Rev Med Chir Soc Med Nat Iasi · Jul 2013
Comparative StudyCorrelations between state anxiety and quality of life in metastatic breast cancer patients.
to evaluate the correlations between perceived state anxiety during chemotherapy and quality of life in metastatic breast cancer patients. ⋯ Higher state anxiety correlates with certain quality of life items, suggesting that psychological counselling and appropriate therapy induced side effects management should be a priority in the palliative care for metastatic breast cancer patients.
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Rev Med Chir Soc Med Nat Iasi · Jul 2013
Some observations on the optimization of pre-hospital emergency medical services from the city of Iasi, Romania.
In the lasi City, with a population of 825,100 inhabitants, the number of requests for ambulance service has increased steadily for the past 17 years. One of the determining factors could be the development of the primary health care prevention. ⋯ The analysis of optimization concept of Medical Services in a city like lasi is about the challenge to understand the impact of the population health towards the development and organizing the territory, and, interrelated, how we can improve the population health by the best possible organization.