Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Dec 2000
Review[New guidelines to evaluate the response to treatment "RECIST"].
Response evaluation criteria in solid tumors (RECIST) guidelines proposes the simplification of response evaluation through the use of unidimensional measurements and the sum of the longest diameters for all target lesions. Data from collaborative studies, including more than 4,600 patients assessed for tumor response, support the simplification of response evaluation through the use of unidimensional measurements in stead of the conventional method using two measurements and the sum of the products. In this criteria, PR is at least a 30% decrease and PD is at least a 20% increase in the sum of the longest diameter of target lesions. ⋯ But, in this criteria, there are some problems in Japanese studies. One of them is that we cannot use the endoscopic findings for the evaluation of gastric cancer except for validation purposes, and one is that long NC (long SD) on breast cancer does not exist in this response criteria. We had discussed these problems at the 38th meeting of Japan Society of Clinical Oncology.
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To assess the burden on families who care for a patients in the terminal stage of cancer at home. ⋯ Monitoring the burden of the family was useful in evaluating the patients' environment at home, and in reconsidering the management of the terminal care at home.
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There are no guidelines for dose escalation methods of combination chemotherapy. Thus, in order to evaluate this method, we selected 30 reports on two drug combination chemotherapies without support by BMT, that were published in the Journal of Clinical Oncology from 1997 to 1999. The present report describes the starting dose, patient number at each dose level, or dose escalation method in these 30 papers.
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Gan To Kagaku Ryoho · Dec 2000
Case Reports[Home drug therapy for a patient who rejected use of morphine--management of dyspnea and pain by codeine phosphate].
We encountered a terminal lung cancer patient with severe back pain and dyspnea who refused the use of morphine, and succeeded in home palliative care with the use of an original prescription (CA), the main ingredient of which was codeine phosphate.