Gan to kagaku ryoho. Cancer & chemotherapy
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Gan To Kagaku Ryoho · Feb 2004
Review[Controversies in breast conservation treatment for breast cancer].
Breast conservation treatment has become the standard treatment for early breast cancer patients, after the equivalence of mastectomy and breast conservation treatment was demonstrated in prospective, randomized trials and large retrospective studies. New questions, such as the feasibility of neoadjuvant chemotherapy in improving breast conserving rate, the appropriateness of breast conservation treatment in ductal carcinoma in situ, the effectiveness of radiation therapy in patients treated by breast conservation, and patient selection for breast conservation without radiation, are now being raised. Future work that needs to be done to answer these questions is discussed in this review.
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Gan To Kagaku Ryoho · Feb 2004
[Current controversy on the effectiveness of mammographic screening for breast cancer in western nations].
In 2000, Olsen and Gøtzsche raised doubt about the results of randomized controlled trials (RCT) on the effectiveness of mammography screening. The paper aroused much criticism, and on October 20, 2001, Olsen and Gøtzsche again published the results of meta-analysis on the effectiveness of screening for breast cancer using mammography. ⋯ Their article in 2001 created worldwide controversy on the effectiveness of screening for breast cancer using mammography. However, breast cancer mortality has declined after introducing the screening mammography in many Western nations, and the guidelines for breast cancer screening were not changed in the countries.