Lijec̆nic̆ki vjesnik
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Lijec̆nic̆ki vjesnik · Jul 2000
Randomized Controlled Trial Clinical Trial[Effect of the menstrual cycle and ondansetron on postoperative nausea and vomiting].
The incidence of postoperative nausea and vomiting (PONV) has been studied in a prospective group of 92 female patients in the generative period, undergoing thyroid surgery. In a subgroup of 47 examinees we analyzed PONV incidence according to the surgery time within the frame of their menstrual cycle. The highest number was observed in periovulatory and premenstrual periods (p < 0.02). In the formal trial, 24 patients that randomly received ondansetron (8 mg in 4 mL i.v.) and significantly less PONV than their 21 placebo controls (4 mL saline i.v.): 4 or 16.8% vs. 11 or 53.6% (p < 0.04).
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Lijec̆nic̆ki vjesnik · Nov 1999
Randomized Controlled Trial Comparative Study Clinical Trial[Comparison between the rubber Carlens tube and the polyvinylchloride Robertshaw tube for endobronchial intubation].
The aims of the study were to compare prospectively two double-lumen endobronchial tubes (DLTs): red rubber Carlens and left polyvinylchloride Robertshaw DLT with regard to difficulties in intubation and complications during one-lung ventilation. Sixty-two adult patients were randomly intubated with Carlens tube (31 patients) or Robertshaw tube (31 patients). Correct placement of DLTs was assessed using clinical signs and in some patients in the Robertshaw group fiberoptic bronchoscope was used. ⋯ In both groups hypoxemia was related to the right side of the operation. Fiberoptic bronchoscope was used in 18 out of 31 patients intubated with the Robertshaw tube. Its use was not correlated with decreased incidence of complications compared to intubation in which tube position was assessed by clinical signs only.
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Lijec̆nic̆ki vjesnik · Jun 1995
Randomized Controlled Trial Clinical TrialThe importance of glucose-insulin-potassium with cardiopulmonary bypass prior to cardioplegic arrest in open-heart surgery.
The benefit of a high dose glucose-insulin-potassium (33% glucose, 80 mmol KCl, 120 units of insulin - 1 mL/kg) (GIK) with cardiopulmonary bypass support (CPB) prior to cardioplegic arrest in open-heart surgery has been evaluated in this article. Twenty non-diabetic patients (PTS) were selected upon their preoperatively impaired left ventricular ejection fraction (LVEF < 45%) and were divided into two groups. Group 1 was given GIK and 20 minutes of CPB prior to cardioplegic arrest; Group 2 was the control group with no GIK and no CPB support. ⋯ At 30 minutes and 24 hours postoperatively there was no significant difference, but clinical difference was observed, probably due to necessary inotropic stimulation in Group 2. There was neither clinical nor statistical difference in right ventricular stroke work index (RVSWI) throughout the whole measurement. The authors emphasise the importance of GIK with CPB in myocardial protection in patients undergoing open-heart surgery.
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Lijec̆nic̆ki vjesnik · Jan 1995
Randomized Controlled Trial Comparative Study Clinical Trial[Effectiveness and adverse effects of a single daily dose of gentamicin versus twice daily administration].
The efficacy and toxicity of a single versus double gentamicin dose were compared. Fifty-four ill patients with infection susceptible to gentamicin in Department of Internal Medicine, University Hospital Rebro, Zagreb, were included in this study. The following criteria excluded patients from the study: serious renal failure (creatinine > 250 mumol/l), hearing impairment, condition and immunodeficiency. ⋯ Ototoxic reaction developed in 35% of the patients on a single gentamicin dose and in 44.8% of the patients on a double dose (P > 0.05), and a lesion was more diffuse in this group. Risk factors for gentamicin ototoxicity were: through gentamicin concentration, duration of therapy, older age and abnormal renal function. Therapeutic effect was observed in 96% of the patients in SG and in 86.2% of the patients in DG (P > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)