Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Mar 2010
[Soft tissue repairing and functional reconstruction in limb salvage operation on extremity bone malignant tumors].
To investigate the effect and the significance of soft tissue repairing and functional reconstruction in limb salvage operation on extremity malignant bone tumors by individualized prosthesis replacement after malignant tumor resection with the help of Neo-adjuvant chemo-therapy. ⋯ Soft tissue repairing and functional reconstruction in limb salvage operation on extremity bone malignant tumors by individualized prosthesis replacement not only spare the limbs, but also keep their function.It can remove the psychologic obstacles caused by extremity absence, and is effective for bone malignant tumor.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Nov 2009
[Methods to determine minimal clinically important difference].
There are 4 methods to determine a minimal clinically important difference (MCID) currently, namely anchor-based method, distribution-based method, opinion-based method, and literature review. The anchor-based method offers the clinical significance of MCID, but it does not consider the measurement error. The anchor-based method is limited due to difficulty to obtained a suitable anchor in most cases, and variation of MCID with the anchor. ⋯ The opinion-based method and literature review are based on the opinions of experts and the published literature, respectively. They are usually regarded as a supplement to anchor-based method and distribution-based method. It is suggested that anchor-based method, distribution-based method, and opinion-based method should be used together when determining a MCID.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Nov 2009
Randomized Controlled Trial[Protective effect of aminophylline on cerebral injury during cardiopulmonary bypass in infants].
To investigate the protective effect of aminophylline on cerebral injury induced by cardiopulmonary bypass (CPB) in infants. ⋯ There is cerebral damage induced by CPB. Aminophylline may play a protective role in cerebral injury by modulating the balance between the pro-inflammatory factor and anti-inflammatory factor to reduce the level of S-100beta protein and NSE during CPB and open cardiac surgeries.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Sep 2009
[Risk factors for acute kidney injury following 5100 cardiac surgeries with extracorporeal circulation].
To determine the incidence and risk factors associated with acute kidney injury (AKI) in patients after cardiac surgery with extracorporeal circulation. ⋯ The incidence of AKI after cardiac surgery with extracorporeal circulation is closely related with a variety of perioperative risk factors. Our data suggest that patients planning to accept cardiac surgery with extracorporeal circulation should be more comprehensively assessed and monitored, thereby preventing the occurrence of AKI.
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Zhong Nan Da Xue Xue Bao Yi Xue Ban · Aug 2009
Randomized Controlled Trial[Multimodal effect of celecoxib on the perioperative analgesia in orthopaedic surgery].
To determine the multimodal postoperative analgesia effect of celecoxib combined with patient-controlled analgesia (PCA) and its clinical efficacy and related adverse events in orthopaedic procedures. ⋯ The multimodal use of the specific COX-2 inhibitor celecoxib in the postoperative period of orthopaedic procedures clearly improves postoperative pain, reduces the opioid consumption, releases the sleep disturbance, demonstrates more satisfaction in patients and lower chronic pain rate after discharge, without affecting the platelet and coagulation function.